Target of interest
Existing large molecule with the intended function on target
Generation of many different de-novo compressed therapeutic molecules that maintain all necessary elements that drive the intended functions
Motif necessary and sufficient for function
Compressed functional design
Compressed functional design
Compressed functional design
Compressed functional design
Compressed functional design vs original large molecule
The input to the platform is a set of disease causing/modifying targets that cannot be targeted due to size limitation on the potential therapeutic molecule
Structural, functional, and dynamic modeling of all relevant factors that matter for achieving the intended therapeutic effect
Identification and characterization of all molecular components that the compressed therapeutic molecule must maintain to achieve the intended functions
The COMPACT™ platform
We’ve built a proprietary platform to compress complex biological structures into smaller, more efficient de novo-designed proteins that retain full functionality, optimizing delivery and therapeutic effectiveness for intractable and hard-to-treat diseases.
Multiple fully functional compressed designs with high function prediction scores, ready for in-vitro and preclinical testing
INPUT
INPUT
READING
READING
ANALYZING
ANALYZING
WRITING
WRITING
OUTPUT
OUTPUT
_gif.gif)
Addressing the size problem
The size of complex therapeutics has become a major limitation in designing, developing, manufacturing, and delivering advanced therapies. As a result, many diseases across multiple treatment modalities, affecting millions of individuals worldwide, have suboptimal therapeutic options. We developed our COMPACT platform to overcome the size problem and usher in a new era in drug development.