Target of interest
Generation of many different de-novo compressed therapeutic molecules that maintain all necessary elements that drive the intended functions
Motif necessary and sufficient for function
Multiple highly functional drug candidates
Multiple highly functional drug candidates
Multiple highly functional drug candidates
Multiple highly functional drug candidates
Multiple highly functional drug candidates
The input to the platform is a set of disease causing targets that cannot be targeted due to size, structure, or function constrains of the intended drug.
Structural, functional, and dynamic modeling of all relevant factors that matter for achieving the intended therapeutic effect
Identification and characterization of all molecular components that the compressed therapeutic molecule must maintain to achieve the intended functions
Multiple fully functional designs with high function prediction scores, ready for in-vitro and preclinical testing
INPUT
INPUT
READING
READING
WRITING
WRITING
NOMINATING
NOMINATING
OUTPUT
OUTPUT
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Pushing the bounaries of protein therapies
Current drugs rely on natural proteins, which are inherently limited in size, structure, and functionality. As a result, many validated drug targets remain out of reach, and numerous diseases lack effective treatments. We developed COMPACT, a de novo protein design platform, to overcome these limitations. Our platform generates highly programmable proteins, creating a new class of drugs designed to cure the incurable and unlock limitless potential.